Shamrock Rovers (IRL) – Progrès Niederkorn (LUX) 3-0 (agg 3-0)
Kayrat Almaty (KAZ) – Crvena Zvezda (SRB) 2-1 (agg 4-1)
Željezničar (BIH) – Balzan (MAL) 1-0 (agg 3-0)
Dacia Chișinău (MOL) – Renova (MKD) 4-1 (agg 5-1)
Koper (SVN) – Víkingur Reykjavík (ISL) 2-2 (agg 3-2)
Odd (NOR) – Sheriff Tiraspol (MOL) 0-0 (agg 3-0)
Torpedo-BelAZ Zhodino (BLR) – Kukësi (ALB) 0-0 (agg 0-2)
St. Johnstone (SCO) – Alashkert (ARM) 2-1 (agg 2-2)
Litex Lovech (BUL) – Jelgava (LET) 2-2 (agg 3-3)
Valletta (MAL) – Newtown (WAL) 1-2 (agg 2-4)
Gabala (AZE) – Dinamo Tbilisi (GEO) 2-0 (agg 3-2)
Spartak Trnava (SVK) – Olimpic (BIH) 0-0 (agg 1-1)
Lusitanos (AND) – West Ham United (ENG) 0-1 (agg 0-4)
Shakhtyor Soligorsk (BLR) – Glenavon (NIR) 3-0 (agg 5-1)
Bala Town (WAL) – Differdange 03 (LUX) 2-1 (agg 3-4)
Aberdeen (SCO) – Shkëndija (MKD) 0-0 (agg 1-1)
Rosenborg (NOR) – Víkingur Gøta (FAR) 0-0 (agg 2-0)
Hafnarfjordur (ISL) – SJK (FIN) 1-0 (agg 2-0)
NSÍ Runavík (FAR) – Linfield (NIR) 4-3 (agg 4-5)
Juvenes/Dogana (SMR) – Brøndby (DEN) 0-2 (agg 0-11)
Vojvodina (SER) – MTK Budapest (HUN) 3-1 (agg 3-1)
St Patrick’s Athletic (IRL) – Skonto (LET) 0-2 (agg 1-4)
Elfsborg (SWE) – Lahti (FIN) 5-0 (agg 7-2)
Beroe Stara Zagora (BUL) – Atlantas (LIT) 3-1 (agg 5-1)
Sutjeska Nikšić (MNG) – Debrecen (HUN) 2-0 (agg 2-3)
Beitar Jerusalem (ISR) – Ordabasy (KAZ) 2-1 (agg 2-1)
Hajduk Split (CRO) – Sillamäe Kalev (EST) 6-2 (agg 7-3)
Spartaks Jūrmala (LET) – Budućnost Podgorica (MNG) 0-0 (agg 3-1)
Rabotnički (MAC) – Flora Tallinn (EST) 2-0 (agg 2-1)
Randers (DEN) – Sant Julià (AND) 3-0 (agg 4-0)
Apollon Limassol (CYP) – Saxan (MOL) 2-0 (agg 4-0)
Nõmme Kalju (EST) – Aktobe (KAZ) 0-0 (agg 1-0)
Omonia (CYP) – Dinamo Batumi (GEO) 2-0 (agg 2-1)
Jagiellonia Białystok (POL) – Kruoja Pakruojis (LIT) 8-0 (agg 9-0)
Zrinjski Mostar (BIH) – Shirak (ARM) 2-1 (agg 2-3)
KR Reykjavik (ISL) – Cork City (IRL) 2-1 dts (agg 3-2)
Ferencváros (HUN) – Go Ahead Eagles (NED) 4-1 (agg 5-2)
HB Torshavn (FAR) – Trakai (LIT) 1-4 (agg 1-7)
Inter Baku (AZE) – Laçi (ALB) 0-0 (agg 1-1)
AIK Solna (SWE) – VPS (FIN) 4-0 (agg 6-2)
F91 Dudelange (LUX) – UC Dublin (IRL) 2-1 (agg 2-2)
Čukarički (SRB) – Domžale (SVN) 0-0 (agg 1-0)
Slovan Bratislava (SVK) – Europa FC (GIB) 3-0 (agg 9-0)
Žilina (SVK) – Glentoran (NIR) 3-0 (agg 7-1)
Partizan Tirana (ALB) – Strømsgodset (NOR) 0-1 (agg 1-4)
Mladost Podgorica (MNG) – Neftchi Baku (AZE) 1-1 (agg 3-3)
Śląsk Wrocław (POL) – Celje (SVN) 3-1 (agg 4-1)
Vaduz (LIE) – La Fiorita (SMR) 5-1 (agg 10-1)
Ulisses (ARM) – Birkirkara (MAL) 1-3 (agg 1-3)
Lokomotiva (CRO) – Airbus UK Broughton (WAL) 2-2 (agg 5-3)
Spartaki Tskhinvali (GEO) – Botoșani (ROM) 1-3 (agg 2-4)